The global regulator SpoVG modulates <i>Staphylococcus aureus</i> virulence through Agr-dependent pathways.

ABSTRACT: Staphylococcus aureus (S. aureus) is a major pathogen responsible for a wide range of infections in both community and healthcare settings. Its virulence is orchestrated by a complex regulatory network. SpoVG, a global regulator in S. aureus, has been shown to play crucial roles in antibiotic tolerance, stress adaptation, and biofilm formation. However, its specific role in virulence regulation has remained poorly understood. Here, we investigated the role of SpoVG in the modulation of S. aureus virulence. The results demonstrate that deletion of spoVG significantly increased the hemolytic activity and virulence of the SA3 strain, as evidenced by both in vitro assays and murine infection models. Transcriptomic profiling and RT - qPCR analyses revealed tha

SUBMITTER: Ma K 

PROVIDER: S-EPMC12445516 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature