Interleukin-1β depresses neuronal activity in the rat olfactory bulb even during odor stimulation.

ABSTRACT: The olfactory system is exposed to external and internal harmful agents that may impair the communication between the olfactory sensory neurons and olfactory brain areas. Inflammatory molecules increase in the olfactory system in response to infections and chronic systemic diseases. Interleukin-1β (IL-1β) is a cytokine produced in many inflammatory processes. In previous studies, we observed that IL-1β increased in the olfactory bulb (OB) of diabetic rats, which also presented olfactory dysfunction. This study aimed to determine whether IL-1β could be responsible for the olfactory impairment. To address this question, IL-1β and its antagonist IL-1Ra were microinjected in the OB of rats to evaluate the electrophysiological activity in the OB and entorhinal cortex (EC) by recording the local

SUBMITTER: Jimenez A 

PROVIDER: S-EPMC12445527 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature