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Scedosporium infection as a late complication after start of elexacaftor/tezacaftor/ivacaftor: two case reports.


ABSTRACT: Highly effective modulator treatment (HEMT) has resulted in an improved prognosis for people with cystic fibrosis (pwCF). In this case report, we present two pwCF with clinical stabilization after start of HEMT who developed complicated fungal infections after several years of clinical stability, highlighting the importance of continued careful monitoring of pwCF on HEMT and considering early antifungal treatment in this population.

SUBMITTER: van Mourik P 

PROVIDER: S-EPMC12445565 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature

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Scedosporium infection as a late complication after start of elexacaftor/tezacaftor/ivacaftor: two case reports.

van Mourik P P   van der Hout E C EC   Luijk H D HD   Hofland R W RW   Bruns A H W AHW   Heijerman H G M HGM   Bronsveld I I  

Respiratory medicine case reports 20250830


Highly effective modulator treatment (HEMT) has resulted in an improved prognosis for people with cystic fibrosis (pwCF). In this case report, we present two pwCF with clinical stabilization after start of HEMT who developed complicated fungal infections after several years of clinical stability, highlighting the importance of continued careful monitoring of pwCF on HEMT and considering early antifungal treatment in this population. ...[more]

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