A traditional Cameroonian spice, Syzygium guineense curtails leukemia tumor growth through G2-M cell cycle arrest and predicted NLRP3 inflammasome pathway.

ABSTRACT:

Background

S. guineense DC. var. macrocarpum (Engl.) F. White. plant has been a traditional Cameroonian spice used as medicine to treat several health conditions such as liver cirrhosis, vaginal infections, and cancer.

Objective

This study aims to investigate the anti-cancer effects of Syzygium guineense plant parts on leukemia preclinical models.

Material and methods

Crude extracts and fractions of S. guineense were tested to inhibit the proliferation of human leukemia cells and reduce tumor volume in leukemia xenograft KG1 in immunodeficient mice. Further active fractions were evaluated for the mechanism of action using cell cycle analysis. Inflammasome markers, key targets of chronic inflammation, were screened from phytoconstituents obtained by LC-MS analysis. Of

SUBMITTER: Nzufo FT 

PROVIDER: S-EPMC12445572 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature