Advances in exploring the association between FMR1 premutation and fibromyalgia: a pilot study with a more effective sample definition.

ABSTRACT:

Introduction

The association between Fibromyalgia (FM) and the FMR1 gene premutation has been suggested, but remains inconclusively established. Previous studies often focus on whether women with FM have the FMR1 premutation, while a more appropriate approach would involve examining FM manifestation in women with the premutation. FM is a condition with multifactorial etiology, and while the rarity of the FMR1 premutation makes it unlikely that most FM cases are linked to this variation, an increased prevalence of FM among premutation carriers is still plausible. The authors present a pilot study with a more effective approach for sample definition that shows a trend toward confirming this association.

Objective

To investigate the association between FM and the FMR1 premutati

SUBMITTER: Pinheiro MMLS 

PROVIDER: S-EPMC12445584 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature