Digital cousins: Simultaneous optimization of one model for BMP signaling in distant relatives reveals essential core.

ABSTRACT: Spatially distributed, nonuniform morphogen gradients play a crucial role in tissue organization during development across the animal kingdom. The Bone Morphogenetic Protein (BMP) pathway, a well-studied morphogen involved in dorsal-ventral (D-V) axis patterning, has been extensively studied in zebrafish, Drosophila, and other organisms. Given that this pathway is highly conserved in both form and function, we sought to determine whether a core mathematical model that constrained topology and biophysical parameters could fully reproduce the observed dynamics of gradient formation in both Drosophila and zebrafish through changes in expression only. We used multi-objective optimization to simultaneously fit a single core model to Drosophila and zebrafish data and conditi

SUBMITTER: Li L 

PROVIDER: S-EPMC12445611 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature