Mechanisms, therapeutic uses, and developmental perspectives of redox-active thiomolybdates.

ABSTRACT: Redox-active, copper-chelating thiomolybdates are a family of metal-based therapeutics used to treat copper toxicity in animals and Wilson's disease in humans, and studied in other indications including cancer, inflammatory and fibrotic conditions. Thiomolybdates act through multiple mechanisms including copper chelation, redox regulation (e.g., superoxide dismutase inhibition), and modulation of inflammation. We and others have also identified thiomolybdates as slow-release sulfide donors that inhibit mitochondrial respiration, limit mitochondrial reactive oxygen species (ROS) production, augment antioxidant reserve capacity, and confer organ- and whole-body protection in non-clinical models of reperfusion injury. Here we review the rich history of the thiomolybdate drug class, focusing o

SUBMITTER: Wu Y 

PROVIDER: S-EPMC12445612 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature