Somatic mutations in Middle East and North Africa breast cancer patients: a systematic review.

ABSTRACT:

Background

Breast cancer presents with distinct clinical and molecular characteristics in the Middle East and North Africa (MENA) region, where women are diagnosed at younger ages and with more aggressive disease compared to Western populations. Despite the global burden, genomic studies of breast cancer in MENA remain underrepresented. This systematic review provides the first comprehensive analysis of somatic mutations in breast cancer patients across the MENA region.

Methods

Following PRISMA guidelines, we analyzed 44 studies encompassing 13 MENA countries, representing data from over 2500 breast cancer patients. Studies were rigorously assessed using the Newcastle-Ottawa Scale, with mutation data extracted, standardized, and classified according to pathogenicity using es

SUBMITTER: Abujamous L 

PROVIDER: S-EPMC12445638 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature