Preclinical efficacy of adipose-derived cell therapies for the treatment of myositis.

ABSTRACT:

Importance

Idiopathic inflammatory myopathies, commonly referred as myositis, are autoimmune diseases that cause muscle damage, progressive weakness, and disability. Current treatments, including corticosteroids and immunosuppressants, have significant limitations, highlighting the need for new therapies.

Objective

This preclinical study explored the therapeutic potential of adipose tissue-derived cell therapies, specifically stromal vascular fraction (SVF) and adipose-derived stem cells (ADSC), using an Icos-/- NOD mouse model of spontaneous myositis.

Design

SVF and ADSC were extracted from CD1 female mice adipose tissue and cultured. Various doses were injected intramuscularly into the right hind limb of 20- to 22-week-old female Icos-/- NOD mice with a control grou

SUBMITTER: Pileyre B 

PROVIDER: S-EPMC12445652 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature