Electrostatic Loading and Photoredox-Accelerated Release of Antibiotics from Oligoviologen-Crosslinked Hydrogels Using Red Light.

ABSTRACT: Hydrogel drug delivery is the subject of an ever-expanding industry where delivery occurs by numerous methods, many of them passive in nature. On-command, stimuli-driven release, particularly using light to initiate spatiotemporal, controlled release of cargo is a more attractive approach than passive release methods. Here, we report a novel method for electrostatically loading negatively charged dye and antibiotic cargo in biocompatible, oligoviologen-crosslinked hydrogels equipped with an integrated Aza-boron-dipyrromethene (Aza-BODIPY) photocatalyst. Following loading, the release of the electrostatically bound cargos can be accelerated upon irradiation with red light (660 nm) through a photoinduced electron transfer (PET) process that reduced the oligoviologen subunits. A free radical

SUBMITTER: Dorsainvil JM 

PROVIDER: S-EPMC12445729 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature