Application efficacy of dural puncture epidural versus traditional combined spinal epidural for labour analgesia: A systematic review and meta-analysis with trial sequential analysis.

ABSTRACT:

Background and aims

This study aimed to systematically evaluate the effectiveness and safety of dural puncture epidural (DPE) and combined spinal epidural (CSE) for labour analgesia in parturients.

Methods

Searches were performed in PubMed, Embase, Web of Science, Cochrane Library, CNKI, Wanfang Database, VIP Database, and CBM Database up to June 2025 to identify randomised controlled trials (RCTs) investigating the application of DPE and CSE techniques for labour analgesia in parturients. Data from eligible studies were pooled to calculate the combined standardised mean difference (SMD) or risk ratio (RR).

Results

Eleven studies with 1461 parturients were included. DPE had higher visual analogue scale (VAS) pain scores at 10 min [SMD: 0.60; 95% confidence interval (C

SUBMITTER: Qin J 

PROVIDER: S-EPMC12445766 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature