Study of brain perfusion in adults with Down syndrome along the Alzheimer's disease continuum.

ABSTRACT:

Introduction

We assessed pseudo-continuous arterial spin labeling (pCASL) sensitivity to detect changes in cerebral blood flow (CBF) in adults with Down syndrome (DS) along the Alzheimer's disease (AD) continuum and explored the similarity with sporadic AD (sAD) hypoperfusion profile.

Methods

Fifty-one euploid cognitively unimpaired individuals, 54 adults with DS (34.54% symptomatic for AD), and 25 sAD patients underwent 3T magnetic resonance imaging. pCASL images were preprocessed using ASLprep. Analyses explored, globally and regionally, the effects of demographic variables, clinical stages, and AD biomarkers.

Results

Age and sex differently impacted CBF in euploids versus the DS population. Asymptomatic DS showed temporo-parietal hypoperfusion, extending into front

SUBMITTER: Franquesa-Mullerat M 

PROVIDER: S-EPMC12445992 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature