Single-cell RNA sequencing in studies of type 1 diabetes mellitus: modern state-of-the-art and technical peculiarities.

ABSTRACT: Type 1 diabetes mellitus (T1DM) is an autoimmune disease leading to destruction of pancreatic β-cells and loss of insulin production ability. Pathogenesis of T1DM is a complex process involving different types of immune cells, particularly, T-lymphocytes (including effector cells, Thelpers, regulatory lymphocytes, MAIT cells), B-lymphocytes, natural killers, monocytes, dendritic cells, and other minor cellular populations that form autoimmune response against islet cells. The heterogeneity of intercellular communications in the pancreas and adjacent lymph nodes of patients, as well as diverse functional state of islet cells, make a significant contribution to the pathogenesis of this disease. This makes the detailed consideration of immune cell subpopulations very essential for inve

SUBMITTER: Abdullatypov AV 

PROVIDER: S-EPMC12446015 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature