Ocular and systemic immune profiles associated with cystoid macular edema in retinitis pigmentosa.

ABSTRACT:

Purpose

We aimed to investigate the local and systemic inflammatory profiles associated with cystoid macular edema (CME) in patients with retinitis pigmentosa (RP).

Patients and methods

Paired aqueous humor and serum samples were collected at the time of cataract surgery from 37 eyes of 37 patients with typical RP, including 29 without CME and eight with CME. The concentrations of cytokines and chemokines were determined using a multiplexed immunoassay (Q-Plex). Group comparisons were conducted to assess differences in the inflammatory molecule levels between the RP patients with and without CME. Correlations among the intraocular parameters, the systemic inflammatory molecules, and the CME status were analyzed.

Results

Compared to RP patients without CME, those with

SUBMITTER: Tao Y 

PROVIDER: S-EPMC12446031 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature