Identifying pyroptosis-hub genes and immune infiltration in neonatal hypoxic-ischemic brain injury.

ABSTRACT:

Background

Hypoxic-ischemic encephalopathy (HIE) is a leading cause of neonatal brain injury and neurodevelopmental disorders. Pyroptosis, an inflammatory programmed cell death, may offer new therapeutic targets for HIE by modulating cytokine expression and related pathways. This study aims to identify HIE-associated pyroptosis genes and explore potential drugs and molecular mechanisms.

Methods

The gene microarray data of hypoxic-ischemic brain damage (HIBD) were obtained from the Gene Expression Omnibus (GEO) database. The Limma package was used to identify differentially expressed genes (DEGs). Weighted gene co-expression network analysis (WGCNA) was performed to find significant expression modules. GO and KEGG analyses were carried out for the pathway enrichment of DEGs,

SUBMITTER: Qin C 

PROVIDER: S-EPMC12446038 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature