Benefits and challenges of multi-delay arterial spin labeling in clinical practice: measuring perfusion and cerebrovascular reactivity in intracranial steno-occlusive disease.

ABSTRACT: Magnetic resonance imaging (MRI) techniques have now widely replaced positron emission tomography (PET) as the modality of choice to assess cerebrovascular reactivity (CVR) and other hemodynamic parameters in intracranial steno-occlusive disease (ISOD), such as moyamoya vasculopathy (MMV). Therefore, radiologists should be aware of the choices in imaging techniques and potential pitfalls in the imaging interpretation. We developed a protocol based on multi-delay arterial spin labeling (ASL), with which, since its implementation in routine clinical practice in 2018, approximately 100 patients have been evaluated for CVR and other parameters. The protocol demonstrates clinical feasibility and utility, allowing detailed cerebral hemodynamic evaluations of individual patients that are useful f

SUBMITTER: Uniken Venema SM 

PROVIDER: S-EPMC12446178 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature