Associations of Physical Frailty, Social Deficits, and Cognitive Impairment with Risk of 45 Incident Non-Communicable Diseases: The Mediating Role of Accelerated Biological Aging-A Prospective Cohort Study.

ABSTRACT:

Objectives

Frailty extends beyond a physical construct to encompass cognitive and social functioning. We aimed to assess the associations of these impairments, individually and in combination, with the risk of 45 non-communicable diseases (NCDs), and explore the role of accelerated biological aging.

Design and setting

A prospective cohort study was conducted using data from the UK Biobank.

Participants

A total of 427,026 participants with physical data, 171,269 with social data, and 49,820 with cognitive data were included in analysis.

Measurements

Physical frailty, social deficits, and cognitive impairment were assessed using self-reported data and anthropometric measurements, while biological age was calculated based on blood chemistry and clinical data. Haza

SUBMITTER: Pei B 

PROVIDER: S-EPMC12446211 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature