Molecular pathogenesis of Alzheimer's disease onset in a mouse model: effects of cannabidiol treatment.

ABSTRACT:

Introduction

Alzheimer's disease (AD) is a common neurodegenerative condition involving a complex blend of disturbances in synaptic development and maintenance, neurovascular cross-talk, ionic and nutrient transport, and mitochondrial metabolism. The precise molecular profile of AD onset with insight for major pathological contributors remains unclear with corresponding impedances in therapeutic development. The current study sought two objectives, as (i) to resolve the molecular pathogenesis from cognitive impairment to the onset of AD-like neuropathology and (ii) whether the novel agent cannabidiol (CBD), noted for its neuroprotective effects, influences the molecular transition associated with AD onset.

Methods

Dietary CBD was administered daily (80-100 mg/kg/day) in male

SUBMITTER: Bishara MA 

PROVIDER: S-EPMC12446314 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature