Late vs. early intrauterine blood transfusion in fetal anemia: impact on maternal and neonatal outcomes.

ABSTRACT:

Introduction

Optimal timing of final intrauterine transfusion (IUT) and delivery in fetal anemia remains controversial, balancing procedural risks against prematurity complications. Our objective is to evaluate the safety and effectiveness of extending IUT beyond 34 weeks gestation in appropriately selected cases.

Methods

Retrospective cohort study comparing pregnancies receiving late IUT (≥34 weeks, n = 21) versus early IUT (<34 weeks, n = 31) at a single tertiary center (2005-2024). We analyzed 200 IUT procedures in 52 pregnancies. Late IUT was offered to stable cases without hydrops or previous significant complications. Primary outcomes included procedure-related complications and prematurity-related outcomes.

Results

Late IUT showed no increase in p

SUBMITTER: Cahen Peretz A 

PROVIDER: S-EPMC12446343 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature