Correlation between blood urea nitrogen/albumin levels and 30-day all-cause mortality in critically Ill patients with heart failure: a retrospective cohort study and predictive model development based on machine learning.

ABSTRACT:

Objective

The aim of this study was to investigate the correlation between blood urea nitrogen-albumin index (BAR) and 30-day and one-year all-cause mortality in patients with heart failure admitted to the intensive care unit (ICU).

Method

This is a retrospective cohort study with data from two non-overlapping datasets from the Medical Information Marketplace in Intensive Care (MIMIC), where MIMIC-IV was used for training and MIMIC-III for external validation. Risk ratios (HR) and 95% confidence intervals (CI) between the BAR index and all-cause mortality were assessed using Cox proportional risk regression and Kaplan-Meier curves. Restricted cubic spline regression modeling was used to assess potential nonlinear relationships between BAR indices and outcome indicators. Nine

SUBMITTER: Sun WT 

PROVIDER: S-EPMC12446357 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature