Genomic Surveillance and Phylogenetic Analysis of Monkeypox Virus Sampled from Clinical Monkeypox Cases and Sewage - Sichuan Province, China, 2023.

ABSTRACT:

Introduction

Monkeypox (Mpox) has reemerged globally, with thousands of confirmed cases reported in China. However, limited data exist on the genomic variations and transmission patterns of monkeypox virus (MPXV) in southwestern China.

Methods

Clinical samples from Mpox cases and sewage samples from wastewater treatment plants were collected from Sichuan Province for whole-genome sequencing and MPXV analysis.

Results

In the second half of 2023, 96 clinical samples from Mpox patients were collected, yielding 58 full-length viral genomes. All sequenced viruses belonged to the Western African clade (IIb), comprising three C.1 and fifty-five C.1.1 sequences. This study determined that Mpox cases in Sichuan originated from both importation and subsequent local transmission

SUBMITTER: Cao R 

PROVIDER: S-EPMC12446377 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature