Salmon nasal cartilage proteoglycan up-regulates <i>Listeria monocytogenes</i>-mediated immune response in mice.

ABSTRACT: Proteoglycan (PG) is a complex glycohydrate that is widely distributed in the extracellular matrix. We have reported that daily oral administration of PG extracted from salmon (Oncorhynchus keta) nasal cartilage modulates the severity and proinflammatory cytokine responses in Escherichia coli-stimulated macrophages, and attenuates mouse models of various inflammatory diseases. Thus, PG has shown anti-inflammatory activities. In this study, we investigated the effect of salmon nasal cartilage PG on a bacterial infection by using a mouse model of infection with Listeria monocytogenes, which is a facultative intracellular pathogen. PG enhanced production of cytokines including TNF-α, IL-6, IL-12 and IL-10 by heat-killed L. monocytogenes in macrophages and dendritic

SUBMITTER: Nakane A 

PROVIDER: S-EPMC12446387 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature