Determinants of visual functions in patients with early and intermediate age-related macular degeneration: the PEONY study.

ABSTRACT:

Background/objectives

Although decline in visual functions have been reported in eyes with non-advanced age-related macular degeneration (AMD), it is not known if visual functions in these eyes are influenced by structural changes on optical coherence tomography (OCT). We investigated the association between known OCT changes with photopic and scotopic visual functions.

Subjects/methods

Participants aged 55 years or over with early or intermediate AMD in at least 1 eye, and controls with healthy maculae and were included. Associations between visual functions and retinal structural changes were investigated using linear regression and survival analysis.

Results

We found that the presence of refractile drusen and nascent geographic atrophy (nGA) and were associated wit

SUBMITTER: Tang F 

PROVIDER: S-EPMC12446449 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature