Dual-specificity mitogen-activated protein kinase kinases can use ADP to phosphorylate MAP kinases invitro.

ABSTRACT: Kinases are a diverse group of enzymes that use ATP to phosphorylate a variety of substrates. Protein kinases evolved in eukaryotes as important mediators of cell signaling that target specific amino acid side chains to modulate downstream protein function. Among them, the mitogen-activated protein kinases (MAPKs) are a family of intracellular protein kinases that form signaling cascades responding to a number of stimuli, which control fundamental mechanisms such as proliferation, differentiation, inflammation, and cell death. Signals propagate through consecutive kinases which eventually phosphorylate and activate a MAPK. Here, we show that the dual-specificity threonine/tyrosine mitogen-activated protein kinase kinases (MAP2Ks or MEKs) are able to phosphorylate and activate their substra

SUBMITTER: Juyoux P 

PROVIDER: S-EPMC12446509 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature