Hybrid therapeutic agents for self-oxygenating wound therapy via infectious microenvironment modulation.

ABSTRACT: Artificial enzymes mimicking natural processes offer promising solutions for treating infections, but their development faces challenges in synthesis complexity and therapeutic performance. We present a modular-assembly strategy to construct hierarchical MOF@COF heterostructures through covalent interface engineering, bypassing the need for function-specific monomer synthesis while amplifying functionality. By growing porphyrin-based COF shell on amino-functionalized Fe-MIL-88A MOF core, we achieved a morphology-controlled core-shell architecture with well-defined heterojunctions. This hybrid integrates the MOF's dual peroxidase- and catalase-like activities with the COF's photoactivity, enabling cascade therapeutic effects. MOF@COF selectively converts endogenous H₂O₂

SUBMITTER: Guo T 

PROVIDER: S-EPMC12446510 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature