Effect of Cystic Fibrosis Transmembrane Conductance Regulator Modulators on Liver Enzymes Among Patients With Cystic Fibrosis: A Systematic Review and Meta-Analysis.

ABSTRACT:

Backgrounds and aims

This paper seeks to use existing literature to investigate the use of Cystic Fibrosis Transmembrane Conductance (CFTR) modulators and their safety and effects on the liver enzymes of cystic fibrosis (CF) patients with and without related liver disease (CFLD). This review examines the effect of CFTR modulators on liver enzymes as well as their safety profile.

Methods

A comprehensive literature review across Pubmed/Medline, Embase, CINAHL, Cochrane, and Web of Science, was performed. Six articles pertaining to CFTR modulator use and liver enzyme information were included. Statistical evaluation was completed using random-effect models with a 95% confidence interval (CI), and group mean differences were analyzed with R software. Forest plots were generated

SUBMITTER: Vongsavath T 

PROVIDER: S-EPMC12446518 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature