Antimicrobial hydrogel loaded with broccoli exosomes promotes anti-scarring healing of MRSA-infected wounds.

ABSTRACT: The treatment of methicillin-resistant staphylococcus aureus (MRSA)-infected wounds is severely challenged by antibiotic resistance and persistent inflammation. In this study, a photocrosslinked composite hydrogel material (SK@E-Au@Exos) was designed using silk protein methacryloyl hydrogel (SK) as a carrier loaded with broccoli-derived exosomes (Bro-Exos) and epigallocatechin gallate-gold nanoparticles (E-Au NPs). The material promoted scarless wound repair through synergistic anti-infection combined with immune regeneration modulation. In vitro experiments showed that SK@E-Au@Exos has excellent biocompatibility and can rapidly kill MRSA and E.coli, remove Reactive Oxygen Species (ROS), inhibit inflammation, and promote cell proliferation, migration, and vascularization. Importantly, SK@E

SUBMITTER: Duan X 

PROVIDER: S-EPMC12446615 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature