Newcastle disease virus exploits the phospholipid flippase ATP11c-CDC50A complex to promote viral infection.

ABSTRACT: Newcastle disease virus (NDV), a highly contagious avian pathogen, causes significant economic losses in the poultry industry. As an enveloped, negative-sense single-stranded RNA virus, NDV infection and replication are intricately linked to host lipid metabolism, particularly phospholipids like phosphatidylserine (PS). PS asymmetry across the plasma membrane, maintained by phospholipid flippases, such as the ATP11c-CDC50A complex, is crucial for cellular homeostasis but can be exploited by viruses. However, the specific roles of PS and its dynamic regulation by flippases during NDV infection remain unclear. In this study, we investigated how NDV utilizes host PS and the ATP11c-CDC50A complex to facilitate its life cycle. We found that the phospholipid flippase ATP11c-CDC50A complex mainta

SUBMITTER: Zhang D 

PROVIDER: S-EPMC12446626 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature