Mitochondrial lipidome's fatty acid profile and peroxidation index are programmed tissue-specific traits.

ABSTRACT: Mitochondria are dynamic systems adapted to the different cellular demands. In this context, it is hypothesized that lipids, and particularly fatty acids, are also affected by these adaptations and supported at transcriptional level. By analyzing seven mammalian organs from rats, covering the three germ layers and belonging to the four basic types of tissue, we evaluated the differences in the lipidome's fatty acid profiles, calculated fatty acid-derived parameters including susceptibility to lipid peroxidation, and estimated enzymatic activity. Then, we analyzed gene expression datasets of rat tissues to identify specific signatures supporting fatty acid profiles and extended the analysis to human datasets to evaluate shared and differential traits. Our findings demonstrate that a) mitoch

SUBMITTER: Mota-Martorell N 

PROVIDER: S-EPMC12446647 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature