BimA_Bm positivity in melioidosis and its impact on clinical profile, and outcomes: a retrospective cohort study.

ABSTRACT:

Objectives

Melioidosis, caused by Burkholderia pseudomallei presents with diverse clinical features. Neurological involvement, though rare, is a severe complication. The BimA_Bm allele, a variant of the Burkholderia intracellular motility A (BimA) virulence gene, has been linked to neurotropism, but data from India on this association are limited.

Methods

We conducted a retrospective cohort study of 138 culture-confirmed melioidosis patients at a tertiary care center in southern India. A polymerase chain reaction assay was used to detect the BimA_Bm allele in archived isolates. Clinical features and 28-day mortality were compared between BimA_Bm -positive and -negative groups.

Results

The BimA_Bm allele was detecte

SUBMITTER: Gupta N 

PROVIDER: S-EPMC12446652 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature