Bioactive recombinant human elastin gel for reconstructing elastic fibers and rejuvenating endogenously aged skin.

ABSTRACT: Endogenous skin aging results in oxidative stress and degradation of elastic fibers, leading to reduced skin elasticity and dermal laxity. Current treatments rarely target elastic fiber regeneration. Here, we introduce a bioactive gel containing recombinant humanized elastin (RHE) that effectively restores skin elasticity and promotes extracellular matrix remodeling. RHE gel demonstrated superior efficacy in reversing UV-induced damage and oxidative stress in zebrafish models, and significantly improved skin function in aged mice, outperforming commercial vitamin E and recombinant humanized collagen (RHC) gels. Molecular analyses revealed enhanced expression of key elastic fiber and collagen components alongside reduced matrix-degrading enzymes. This study highlights RHE gel's potential as

SUBMITTER: Yang Y 

PROVIDER: S-EPMC12446672 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature