P53 promote oxidative stress, neuroinflammation and behavioral disorders via DDIT4-NF-κB signaling pathway.

ABSTRACT: Depression is a mood disorder characterized by persistent emotional and behavioral dysregulation. Oxidative stress-induced neuronal damage is increasingly recognized as a critical risk factor contributing to the pathogenesis of depression. However, the potential molecular mechanisms and therapeutic targets underlying brain homeostasis disruption induced by neuroinflammatory responses remain unclear. The polyphenolic compound curcumin has been shown to exert neuroprotective effects and partially alleviate depression-related behavioral symptoms through its anti-oxidative properties. However, the molecular mechanisms and therapeutic targets underlying curcumin's ability to ameliorate oxidative stress-induced behavioral abnormalities in specific brain regions remain insufficiently defined. In

SUBMITTER: Zhang K 

PROVIDER: S-EPMC12446673 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature