Lung function impairment and eosinophilia in patients with eosinophilic chronic rhinosinusitis.

ABSTRACT:

Background

Eosinophilic chronic rhinosinusitis (ECRS) is characterized by intense eosinophil infiltration in nasal polyps (NPs), related to asthma comorbidity and elevated circulating eosinophil levels. The mechanism by which these systemic components affect type 2 inflammation in NPs is poorly understood.

Objective

We sought to evaluate the relationship between lung function and eosinophilia in chronic rhinosinusitis and assess whether ECRS reflects lower airway involvement and systemic eosinophilic inflammation.

Methods

We examined 198 patients with chronic rhinosinusitis. Lung function was assessed preoperatively using spirometry and fractional exhaled nitric oxide (Feno). Patients were classified into ECRS and non-ECRS groups on the basis of the Japanese Epidemiol

SUBMITTER: Sonoda Y 

PROVIDER: S-EPMC12446768 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature