Pointwise Structure-Function Analysis of the Ellipsoid Zone in Retinitis Pigmentosa Using an Artificial Intelligence-Assisted OCT and Microperimetry Overlay.

ABSTRACT:

Objective

To perform a pointwise structure-function analysis of the ellipsoid zone (EZ) in retinitis pigmentosa (RP) using an artificial intelligence-based overlay to understand EZ structure-function relationships.

Design

A single-center retrospective study.

Subjects

Patients with clinically confirmed RP.

Methods

Same-day spectral-domain OCT (SD-OCT) and microperimetry near-infrared images were overlaid in patients with confirmed RP. Overlay used a coarse alignment artificial intelligence model. Each locus, on a 68-point microperimetry grid spanning the central 20° of the macula, was identified on individual SD-OCT B-scans. Ellipsoid zone structure was graded at each locus on a 3-point scale: grade 0 = EZ not visible; grade 1 = EZ attenuated; grade 2 = EZ norma

SUBMITTER: Most JA 

PROVIDER: S-EPMC12446769 | biostudies-literature | 2025 Nov-Dec

REPOSITORIES: biostudies-literature