TORC2 and MAPK signaling pathways regulate mitochondrial degradation induced by iron starvation in Schizosaccharomyces pombe.

ABSTRACT: Iron is essential for life as it participates in metabolic processes, including DNA synthesis, respiration, and photosynthesis. In this study, we show that iron starvation induced by 2,2'-dithiodipyl (DIP) causes mitochondrial dysfunction, impairs mitochondrial function, including mitochondrial membrane potential (ΔΨ_m) and respiration, and induces mitochondrial degradation in the vacuole of Schizosaccharomyces pombe. The DIP-induced mitochondrial degradation is independent of components of the core autophagy machinery and the ESCRT machinery examined here. We demonstrate that the target of rapamycin complex 2 (TORC2) and its sole target, the AGC kinase Gad8, and the mitogen-activated protein kinase (MAPK) Sty1 play positive roles in regulating iron starvation-induced mitochondri

SUBMITTER: Li R 

PROVIDER: S-EPMC12446770 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature