Egg desensitization is achieved effectively and safely through a low maintenance dose protocol.

ABSTRACT:

Background

Egg allergy is a common IgE-mediated food allergy in children. Oral immunotherapy (OIT) reduces allergic reactions via gradual allergen exposure. Although high maintenance doses (1-6 g egg protein) are often used, they carry higher risks of adverse reactions. Evidence on the safety and effectiveness of lower-dose egg OIT (E-OIT) remains limited.

Objective

We sought to determine whether a low dose of 300 mg E-OIT is safe and effective for desensitization.

Methods

Twenty-two participants were recruited from the Montreal Children's Hospital; 20 were randomized to an immediate-treatment group or an observation group (egg avoidance for 1 year before OIT). Cumulative tolerated dose (CTD), Gal d 1- and Gal d 2-specific IgE (sIgE) and -specific IgG4 (sIgG4), and sk

SUBMITTER: Toscano-Rivero D 

PROVIDER: S-EPMC12446774 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature