Utidelone induces mechanical and cold allodynia in mice via TRPA1 activation.

ABSTRACT:

Objective

Utidelone (UTD1), a recently approved epothilones analog in China for metastatic breast cancer, is endorsed in combination with capecitabine for metastatic breast cancer patients who have encountered first-line therapy failures. Despite its clinically verified therapeutic efficacy, it is concurrently associated with peripheral neuropathic pain, particularly affecting extremities. However, the etiology of UTD1-induced peripheral neuropathic pain remains unclear.

Methods

The present investigation built a mouse pain model induced by UTD1, resulting in marked mechanical and cold allodynia.

Results

Examination of the dorsal root ganglia unveiled a notable upregulation of TRPA1, accompanied by noteworthy alterations in oxidative stress-related markers, including A

SUBMITTER: Gao W 

PROVIDER: S-EPMC12446820 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature