Low Intensity Thermal Stimulation to Enhance Early Osteointegration in Implants: A Preclinical Study in Rabbits.

ABSTRACT:

Objectives

This study is the first to integrate 3D finite element modeling, in vitro validation, and preclinical animal experiments to determine the efficacy of low-intensity thermal stimulation (LITS) in enhancing dental implant osseointegration. The study seeks to provide experimental evidence for applying thermal stimulation as a possible approach to enhance osseointegration.

Material and methods

A 3D finite element implant-femur model and in vitro implant-bone system were developed to simulate heat distribution. LITS conditions (50°C/5 s) were validated to avoid exceeding the osteoblast safety threshold (47°C). Eighteen rabbits received femoral implants divided into: control (no heating), T1 (single 50°C/5 s heating cycle), and T2 (three cycles). Outcomes included implan

SUBMITTER: Xiufeng Z 

PROVIDER: S-EPMC12446874 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature