Protection of Adipose Tissue by Pioglitazone in a Mouse Model of Doxorubicin Treatment.

ABSTRACT: Cancer is a global epidemic with increasing incidence, which needs continuous efforts to enhance treatment efficacy and reduce side effects. Our study focuses on the impact of doxorubicin, a widely used chemotherapeutic agent, on white adipose tissue (WAT) homeostasis and explores the potential mitigating effects of coadministration with pioglitazone, a peroxisome proliferator-activated receptor-gamma (PPARγ) activator. Using male C57BL/6 mice, we investigated the influence of doxorubicin and pioglitazone on WAT, considering factors such as weight loss, metabolic parameters, lipolysis, adipokines, and immune cell infiltration. Doxorubicin treatment resulted in weight loss, specifically affecting visceral adipose tissue, while coadministration with pioglitazone preserved inguinal adipose ti

SUBMITTER: Silveira LS 

PROVIDER: S-EPMC12446893 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature