Exploring the clinical value of probiotics in the perioperative management of colorectal cancer: Meta-analysis with trial sequential analysis.

ABSTRACT: Colorectal cancer (CRC) is the third most common malignant neoplasm, and there is currently no consensus on the clinical value of probiotics in perioperative CRC. A meta-analysis combined with a trial sequential analysis (TSA) was performed to assess the efficacy and safety of probiotics in the adjuvant treatment of CRC to provide an evidence-based recommendation for perioperative CRC. The present meta-analysis adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and the study protocol was registered with the International Prospective Register of Systematic Reviews (CRD42024510734). The meta-analysis demonstrated that probiotics significantly reduced the incidence of postoperative infections in patients who underwent CRC surgery (risk ratio, 0.54; 95

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12446898 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature