Meta-analysis of the association between long non-coding RNA maternally expressed gene 3 polymorphisms and cancer susceptibility.

ABSTRACT: The long non-coding RNA (lncRNA) maternally expressed gene 3 (MEG3) polymorphism is associated with cancer risk, however, the results have been inconsistent. Therefore, the present meta-analysis aimed to explore the associations between MEG3 polymorphisms and cancer risk. Online databases were searched and reviewed up to December 2024 for eligible studies. Odds ratios (ORs) and corresponding 95% CIs were calculated to assess the underlying association with genetic models. Furthermore, heterogeneity tests, sensitivity and accumulative analysis and publication bias assessment were conducted to evaluate the robustness of the results. There were 24 publications comprising 45 independent case-control studies included in the present meta-analysis. The pooled results revealed a markedly increased

SUBMITTER: Hu YY 

PROVIDER: S-EPMC12446900 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature