The Role of Peritoneal Interleukin-6 in Predicting Patient Survival on Peritoneal Dialysis.

ABSTRACT:

Introduction

Systemic inflammation predicts cardiovascular events and mortality in patients on peritoneal dialysis (PD). Peritoneal inflammation potentially causes adverse outcomes by increasing peritoneal solute transfer rates (PSTRs); however, the extent to which it contributes to systemic inflammation is uncertain. We sought to quantify the longitudinal interrelationship between peritoneal and systemic inflammation, to understand whether peritoneal or systemic inflammation should be targeted to reduce mortality.

Methods

We used patients recruited to the GLOBAL Fluid Study (GFS) within 90 days of starting PD, with ≥ 3 longitudinal paired dialysate and plasma samples. These were assayed for dialysate and plasma interleukin (IL)-6 levels by electrochemiluminescence (Meso-Sca

SUBMITTER: Elphick EH 

PROVIDER: S-EPMC12446933 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature