A New Prognostic Score Based on Cell-Mediated Immunity for Cytomegalovirus Infection After Transplantation.

ABSTRACT:

Introduction

The interferon gamma (IFN-γ) enzyme-linked immunosorbent spot is a highly sensitive immune assay that enables the assessment of cytomegalovirus (CMV)-specific cell-mediated immunity (CMI) and can identify at-risk transplant patients of CMV infection; however, its clinical implementation remains elusive.

Methods

We developed a novel CMV-CMI risk-score based on the standardized T-SPOT.CMV assay against 2 CMV antigens (immediate-early protein 1 [IE-1] and 65 kDa phosphoprotein [pp65]), a biomarker predicting CMV infection, both high viral replication, and disease by performing a pooled analysis of 570 kidney transplants participating in different clinical trials and subsequently validating it in 146 consecutives solid organ transplants (SOT) in an interventional tr

SUBMITTER: Kervella D 

PROVIDER: S-EPMC12446942 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature