The metabolic endotoxemia and gut microbiota: research trajectories and hot trends across the centuries (1999-2024).

ABSTRACT:

Background

Metabolic endotoxemia, characterized by chronic low-grade elevation of circulating bacterial endotoxins such as lipopolysaccharides derived from Gram-negative bacteria, has emerged as a central focus in metabolic disease research. Notably, emerging evidence highlights the pivotal role of gut microbiota in driving this condition, though critical knowledge gaps persist regarding the precise mechanisms mediated by gut microbiota-derived metabolites and their specific signaling pathways, as well as the development of individualized intervention strategies. To systematically map the evolving research landscape, this review employs bibliometric analysis to identify emerging trends and patterns in understanding the interplay between metabolic endotoxemia and gut microbial commu

SUBMITTER: Jian E 

PROVIDER: S-EPMC12446963 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature