Left ventricular pressure-loading improves pressure-induced right ventricular remodeling by redistributing mechanical load and reducing mechanosignaling.

ABSTRACT: Right ventricular (RV) function under pressure overload (PO) is critical in congenital heart disease outcomes. While moderate left ventricular (LV) pressure-loading has been shown to benefit RV function, the mechanisms and optimal degree of loading remain unclear. This study investigated whether increasing LV afterload could enhance RV function, remodeling, and molecular signaling. Using computational modeling and an in vivo "double-banding" (DB) approach in Sprague-Dawley rats-constricting both the pulmonary artery (PA) and transverse aorta-the effects of LV loading were assessed. Modeling suggested that LV pressure-loading improves RV contractility by homogenizing RV load. In vivo, DB rats exhibited higher tricuspid annular plane systolic excursion (TAPSE) compared to those with only pul

SUBMITTER: Lee XA 

PROVIDER: S-EPMC12447007 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature