Dissolving Microneedle for Maintaining the Integrity of HPV Virus-Like Particles Enabling Durable Sterile Protection Across Various Mucosal Tissues.

ABSTRACT: Human papillomavirus (HPV) vaccines have substantially reduced cervical cancer and other HPV-related diseases in high-income countries, with male vaccination addressing transmission as well as head and neck cancers. However, in low- and middle-income countries, widespread vaccination efforts are hindered by considerable costs, insufficient medical staff, and challenges in maintaining vaccine stability. Conventional microneedle vaccine production often compromises the structural integrity of virus-like particles (VLPs), thereby reducing their effectiveness. To address this challenge, a dissolving microneedle platform is developed that preserves VLP stability for over six months. Administration of this vaccine platform to buccal tissue enables effective antigen delivery, inducing T follicula

SUBMITTER: Kim H 

PROVIDER: S-EPMC12447025 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature