Coagulation Matters: ATIII-Enriched Biomolecular Corona Enhances the Hemocompatibility of PEG Nanoparticles.

ABSTRACT: Nanoparticles in physiological environments acquire a biomolecular corona that defines their biological identity, mediating immune system recognition and accelerating blood clearance of the nanoparticles. Typically, low-fouling materials are chosen to minimize protein adsorption and thereby immune system responses, contributing to stealth in blood. However, absolute prevention of the biomolecular corona remains tantalizingly out of reach. Herein, it is proposed to leverage the biomolecular corona rather than preventing its formation, in order to overcome immune responses toward nanoparticles. Low-fouling and stealthy poly(ethylene glycol)(PEG) nanoparticles are used, with a functional biomolecular corona enriched with anticoagulant heparin-antithrombin III (HEP-ATIII) complexes that can mi

SUBMITTER: Londhe V 

PROVIDER: S-EPMC12447026 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature