Dynamic Relevance Between Reflux Events and Esophageal Motility in Patients With Proton Pump Inhibitor-Refractory Gastroesophageal Reflux Disease.

ABSTRACT:

Objectives

The association between reflux events and esophageal motility abnormality is unclear. We aimed to determine the relevance between reflux events and esophageal motility in proton pump inhibitor (PPI)-refractory gastroesophageal reflux disease (GERD).

Methods

Patients with PPI-refractory or PPI-responsive GERD were enrolled. Ambulatory 24-h esophageal pH-impedance-pressure monitoring was performed. Reflux symptoms, reflux events, and esophageal motility during acid reflux episodes were recorded and compared between the two groups.

Results

Sixty patients with PPI-refractory GERD and 18 with PPI-responsive GERD were included, all of whom had pathological gastroesophageal reflux. There were no significant differences in the major acid reflux parameters (DeMeeste

SUBMITTER: Lin SH 

PROVIDER: S-EPMC12447029 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature