Multienzyme (3-in-1)-Mimicking a Single Nucleobase-Derived Bionanozyme for Versatile Environmental and Biomedical Applications.

ABSTRACT: The quest for efficient, robust, and sustainable solutions in environmental remediation and advanced biosensing has catalyzed significant interest in biomimetic enzymology. Here, a new Bionanozyme, synthesized from a single nucleobase-adenine (A)-coordinated with copper (Cu) in a 2D crystalline structure (A-Cu), is presented. This state-of-the-art A-Cu Bionanozyme, inspired by natural redox enzymes (Laccase (LAC), Catechol oxidase (CO), and Peroxidase (POD)), is synthesized via simple and scalable, green methods including solvent-free co-grinding and natural aqueous evaporation process. A-Cu's unique structure exhibits triple-enzyme-mimicking catalytic activity, enabling it to detect and degrade toxic phenols in contaminated water and perform ultrasensitive colorimetric biosensing for key

SUBMITTER: Vishwakarma S 

PROVIDER: S-EPMC12447034 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature