Different patterns of antimicrobial non-susceptibility of the nasopharyngeal carriage of Streptococcus pneumoniae in areas with high and low levels of PCV13 coverage.

ABSTRACT:

Introduction

The impact of pneumococcal conjugate vaccines (PCVs) on antimicrobial resistance (AMR) in Streptococcus pneumoniae (Spn) among Chinese children remains inadequately characterized. Evidence is also limited on the interaction between vaccination coverage and regional disparities in AMR patterns. This study aims to assess the impact of the 13-valent pneumococcal conjugate vaccine (PCV13) on nasopharyngeal carriage of Spn and antimicrobial nonsusceptibility to commonly used antibiotics among healthy children under five years of age in China.

Methods

In 2022, 737 pneumococci were isolated from 2333 healthy children recruited in 4 areas (Haikou, Wanning, Baisha, and Qiongzhong) in Hainan Province, China. Serotyping and antimicrobial susceptibility tests were performed

SUBMITTER: Wang J 

PROVIDER: S-EPMC12447090 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature